Generating FSH antagonists and agonists through immunization against FSH receptor N-terminal decapeptides
نویسندگان
چکیده
منابع مشابه
FSH LH : FSH ratio
Patient A was a 30-year-old white woman with a longstanding history of primary amenorrhea and infertility. By age 18 the patient had neither menstruated nor demonstrated evidence of normal breast development. At that time she was given oral contraceptives for four cycles and responded with normal vaginal bleeding. Laboratory evaluation at age 18 demonstrated a serum FSH (follicle-stimulating ho...
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Inhibin is released during late prophase by suppressing the FSH secretion without affecting LH secretion. Immunization against inhibin will increase FSH synthesis leading to ovulation rate. As both immunization against inhibin and FSH injection could increase ovulation rate, therefore, an interaction of both treatment should act synergically or addively. Immunized group (n=10) were immunized wi...
متن کاملBoth recombinant African catfish LH and FSH are able to activate the African catfish FSH receptor.
LH and FSH are heterodimeric glycoprotein hormones, composed of a common alpha-subunit non-covalently associated with a hormone-specific beta-subunit. Repeated efforts to isolate catfish FSH (cfFSH) have not been successful and only catfish LH (cfLH) has been purified from catfish pituitaries. Recently, however, we succeeded in cloning the cDNA encoding the putative cfFSHbeta; the cDNAs for the...
متن کاملOvarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype.
Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it would be of great benefit to predict the response of the patients to FSH. To date, no clear-cut predictors of ovarian responsiveness to FSH have been identified. In this study, we investigated the role of...
متن کاملAllosteric activation of the follicle-stimulating hormone (FSH) receptor by selective, nonpeptide agonists.
The pituitary glycoprotein hormones, luteinizing hormone and follicle-stimulating hormone (FSH), act through their cognate receptors to initiate a series of coordinated physiological events that results in germ cell maturation. Given the importance of FSH in regulating folliculogenesis and fertility, the development of FSH mimetics has been sought to treat infertility. Currently, purified and r...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 1999
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0220151